I need the following discussion questions in about 200 words each. Please provide each question with its own references.DQ 1You have studied the essential structural elements of a functional eukaryotic chromosome. Select an essential structural element of interest. What are the implications of this element for research, health, and life span? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.DQ 2Identify a specific disease encountered in your clinical practice or personal life. Can your patient’s understanding of DNA/RNA replication, transcription, and translation affect the management of the disease? Explain. Support your rationale with a minimum of two scholarly sources.RESOURCESLi, D., Xia, H., Li, Z., Hua, L., & Li, L. (2015). Identification of novel breast cancer subtype-specific biomarkers by integrating genomics analysis of DNA copy number aberrations and miRNA-mRNA dual expression profiling. BioMed Research International, 2015, 1-17. https://doi.org/10.1155/2015/746970Calzone, K. A., Kirk, M., Tonkin, E., Badzek, L., Benjamin, C., & Middleton, A. (2018). The global landscape of nursing and genomics. Journal of Nursing Scholarship, 50(3), 249-256. https://doi.org/10.1111/jnu.12380Pellestor, F. (2019). Chromoanagenesis: Cataclysms behind complex chromosomal rearrangements. Molecular Cytogenetics, 12(6). https://doi.org/10.1186/s13039-019-0415-7My Family Health Portrait-http://kahuna.clayton.edu/jqu/FHH/html/index.htmlMODULE 2DQ 1Identify a complex inheritance health issue you encountered in your clinical practice or personal life. How would you approach working with a patient of a complex inheritance health issue? Explain. Support your rationale with a minimum of two scholarly sources.DQ 2Refer to the complex inheritance health issue identified in DQ 1. Given available genetic tests, which would you use to screen and diagnose this issue? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.RESOURCESRosenbaum, P. (2017). The yin and yang of clinical research. Developmental Medicine and Child Neurology, 59(12), 1208. https://onlinelibrary.wiley.com/doi/full/10.1111/dmcn.13553Hussain, S., Moiz, B., Aqeel, S., & Zaidi, N. (2017). Issues in reproductive health in females having inherited bleeding disorders in Pakistan. Haemophilia, 23(4), 367-370. https://doi.org/10.1111/hae.13254MODULE 3DQ 1A multigenerational family health history can facilitate the management of a patient’s disease. What model would you use to create a multigenerational family health history for a patient? Explain. Support your rationale with a minimum of two scholarly sources.DQ 2Why is it important to have a comprehensive health and physical assessment that includes information on environment and genomic influences? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.RESOURCESGoergen, A. F., Ashida, S., Skapinsky, K., de Heer, H. D., Wilkinson, A. V., & Koehly, L. M. (2016). What you don’t know: Improving family health history knowledge among multigenerational families of Mexican origin. Public Health Genomics, 19(2), 93-101. https://doi.org/10.1159/000443473Welch, B. M., Wiley, K., Pflieger, L., Achiangia, R., Baker, K., Hughes-Halbert, C., Morrison, H., Schiffman, J., & Doerr, M. (2018). Review and comparison of electronic patient-facing family health history tools. Journal of Genetic Counseling, 27(2), 381-391. https://doi.org/10.1007/s10897-018-0235-7Canary, H. E., Elrick, A., Pokharel, M., Clayton, M., Champine, M., Sukovic, M., Jung, H. S., & Kaphingst, K. A. (2019). Family health history tools as communication resources: Perspectives from Caucasian, Hispanic, and Pacific Islander families. Journal of Family Communication, 19(2), 126-143. https://doi.org/10.1080/15267431.2019.1580195MODULE 4DQ 1In the past decade there have been many advances in genetics and genomics and their application to health screening, diagnosis, treatment, and prognosis. What recent advancement do you believe is the most significant for your clinical practice? Explain. Support your rationale with a minimum of two scholarly sources.DQ 2Genetic/Genomic factors are known to contribute to variability of pharmacologic responses in some patients. How does the variability of responses result in tailoring pharmacologic agents to the care of these patients? Explain. Support your rationale with a minimum of two scholarly sources.RESOURCESCenters for Disease Control and Prevention. (2020). My family health portrait: A tool from the Surgeon General. http://kahuna.clayton.edu/jqu/FHH/html/index.htmlDocherty, A. R., Moscati, A., Dick, D., Savage, J. E., Salvatore, J. E., Cooke, M., Aliev, F., Moore, A. A., Riley, B. P., Admins, D. E., Peterson, R., Webb, B. T., Bacanu, S. A., & Kendler, K. S. (2018). Polygenic prediction of the phenome, across ancestry, in emerging adulthood. Psychological Medicine, 48(11), 1814-1823. https://doi.org/10.1017/S0033291717003312Berberich, A. J., & Hegele, R. A. (2019). The complex molecular genetics of familial hypercholesterolaemia. Nature Reviews. Cardiology, 16(1), 9-20. https://doi.org/10.1038/s41569-018-0052-6Salloum, R. G., George, T. J., Silver, N., Markham, M-J., Hall, J. M., Guo, Y., Bian, J., & Shenkman, E. A. (2018). Rural-urban and racial-ethnic differences in awareness of direct-to-consumer genetic testing. BMC Public Health, 18(1), 1-6. https://doi.org/10.1186/s12889-018-5190-6MODULE 5DQ 1Health issues in a clinical setting can be influenced by nutrition. Identify a health issue that has been positively influenced by nutrition in your clinic. How does nutrition improve health? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.DQ 2Choose one disorder of malnutrition that is found in your clinical setting or community. What are the genetic and environmental influences on this disorder, including prevalence rates, testing, treatment, and prognosis? How can the doctoral-prepared nurse apply this information into practice? Explain. Support your rationale with a minimum of two scholarly sources.RESOURCESKiechl, S., Pechlaner, R., Willeit, P., Notdurfter, M., Paulweber, B., Willeit, K., Werner, P., Ruckenstuhl, C., Iglseder, B., Weger, S., Mairhofer, B., Gartner, M., Kedenko, L., Chmelikova, M., Stekovic, S., Stuppner, H., Oberhollenzer, F., Kroemer, G., Mayr, M., … Willeit, J. (2018). Higher spermidine intake is linked to lower mortality: A prospective population-based study. American Journal of Clinical Nutrition, 108(2), 371-380.Brown, H. M., Rollo, M. E., De Vlieger, N. M., Collins, C. E., & Bucher, T. (2018). Influence of the nutrition and health information presented on food labels on portion size consumed: A systematic review. Nutrition Reviews, 76(9), 655-677.Study findings on diet and nutrition are outlined in reports from Kennedy Krieger Institute (Environmental influences on health and development: nutrition, substance exposure, and adverse childhood experiences). (2019, February 8). Health and Medicine Week, 447.MODULE 6DQ 1What is the impact of the aging population on both increased health care expenditures and wasted resources? Do genetics play a role? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.DQ 2Identify a method that uses evidence-based data to support new or innovative ways to care for the aging population. What are the anticipated outcomes of employing this method and methods like it? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.RESOURCESHowdon, D., & Rice, N. (2018). Health care expenditures, age, proximity to death and morbidity: Implications for an ageing population. Journal of Health Economics, 57, 60-74. https://doi.org/10.1016/j.jhealeco.2017.11.001Von Wyl, V. (2019). Proximity to death and health care expenditure increase revisited: A 15-year panel analysis of elderly persons. Health Economics Review, 9(1), 1-16. https://doi.org/10.1186/s13561-019-0224-zMODULE 7DQ 1What is the impact of chronic disease on both increased health care expenditures and wasted resources? Do genetics play a role? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.DQ 2Identify a method that uses evidence-based data to support new or innovative ways to care for patients with chronic disease. What are the anticipated outcomes of employing this method and methods like it? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.RESOURCESGleckman, H. (2019). Reimagining the delivery of care for older adults with chronic conditions. Generations, 43(1), 78-84.Clarke, J. L., Bourn, S., Skoufalos, A., Beck, E. H., & Castillo, D. J. (2017). An innovative approach to health care delivery for patients with chronic conditions. Population Health Management, 20(1), 23-30. https://doi.org/10.1089/pop.2016.0076Mao, A. Y., Willard-Grace, R., Dubbin, L., Aronson, L., Fernandez, A., Burke, N. J., Finch, J., & Davis, E. (2017). Perspectives of low-income chronically ill patients on complex care management. Families, Systems, and Health, 35(4), 399-408. https://doi.org/10.1037/fsh0000260MODULE 8DQ 1Choose a news story, published within last 2 years, about genetic or genomic technology. What is the issue presented? From the perspective of an RN or APRN, what are the ethical, cultural, religious, legal, fiscal, and societal implications of the issue? Explain. Support your rationale with a minimum of two scholarly sources.DQ 2There are several issues that undermine clients’ rights to make genetic and genomic-related decisions and then take action. Identify two issues that you have seen undermine these rights in your clinical setting. What are potential solutions for each? What is your role as the patient advocate with each issue? Explain. Support your rationale with a minimum of two scholarly sources.RESOURCESPadela, A. I., & Aparicio, M. K. (2019). Genethics and human reproduction: Religious perspectives in the academic bioethics literature. New Bioethics, 25(2), 153-171.Morrissey, C., & Walker, R. L. (2018). The ethics of general population preventive genomic sequencing: Rights and social justice. Journal of Medicine and Philosophy, 43(1), 22-43. https://doi.org/10.1093/jmp/jhx034Newson, A. J., Leonard, S. J., Hall, A., & Gaff, C. L. (2016). Known unknowns: Building an ethics of uncertainty into genomic medicine. BMC Medical Genomics, 9(1). https://doi.org/10.1186/s12920-016-0219-0
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