Drawing upon the classical management theory, you are to compose an APA-formatted paper addressing the following questions:

• In what way(s) can you identify with this style? How do you differ?
• Name an organization that has adopted this style and describe whether it was successful.
• Consider the following scenario and apply your management style to it. How would you act in your chosen management style? You are the director of Tri-County Home Health Agency and, due to financial reasons, you are to implement an RIF (reduction in force), also known as a lay-off. How will you decide which jobs will have to be eliminated, who will be in on the decision-making process, and how will you notify employees about your decisions?

Your paper should comprise a title page, at least four pages of information, and a reference page with at least three professional sources other than your textbook.

Your completed exercise should follow the conventions of Standard American English (correct grammar, punctuation, etc.). Your writing should be well ordered, logical and unified, as well as original and insightful. Your work should display superior content, organization, style, and mechanics.

Immune Responses

Abnormal immune responses can trigger a range of autoimmune diseases, in which an individual’s immune system is attacking normal tissues in the body. Well-known examples of autoimmune diseases are type 1 diabetes mellitus, lupus, and multiple sclerosis.

Ideally, one would like to harness the immune system to attack abnormal substances or tissues like cancer, while sparing the normal (unaffected) tissue. Many tumor cells produce antigens (proteins) that theoretically ought to trigger an immune response: that is, one’s immune system ought to recognize cancer cells as somehow foreign or abnormal, and thereafter eliminate these cells from the body. The field of cancer immunotherapy is actively pursuing this study.

Tumor antigens may also be useful for diagnostic tests; high levels of tumor antigens could be taken as markers or indicators of cancer. In this assignment, you will be examining levels of tumor-associated antigens (TAAs) as determined from immunoassays (i.e., biochemical tests that measure the concentrations of the tumor-associated antigens in serum samples).

• Download the Excel file MHA610_assignment_3_data.xls, and open it.
• The spreadsheet contains data on 250 individuals: 90 normal individuals from San Diego (the controls), and 160 individuals from Korea and China, all of whom were diagnosed with hepatocellular carcinoma (HCC).
  • Serum samples were taken from the controls and from the cases at time of diagnosis of HCC. Levels of a panel of 12 tumor-associated antigens (TAAs) were assessed via immunoassays in all individuals;
    • The levels are given in the columns with headings Ab14, HCC1, IMP1, KOC, MDM2, NPM1, P16, P53, P90, RaIA, and Survivin. (These are the designations of the 12 TAAs, all of which were thought to be potentially predictive of cancer.)
• The underlying question is whether we can effectively discriminate between the cases and controls on the basis of the levels of these TAAs. This is sometimes termed a classification problem in the statistics and biostatistics literature: we wish to classify individuals as normal or cancer patients on the basis of their TAA levels.
• We will examine these data in Statdisk. Use the MHA610_Week 3_Assignment_Data.CSV file to upload this information into Statdisk.
  • If you choose the latter option, Start Statdisk, then choose File>Open and select the .csv file you created (unless you changed the name, it ought to be MHA610_assignment_3_data.csv)
  • Check the box that specifies the data contains column titles or headers, select Comma separated for how the data are delimited, click finish, and the dataset will have been successfully imported into Statdisk.
  • NOTE: you may want to read through the remainder of the assignment first, before proceeding with this step. This may save you some work afterwards!
• Note that Statdisk operates on columns of data, and that both cases and controls are contained in each column of TAA levels. It will be necessary to separate the cases and controls for further analyses. This can be accomplished either by copying within Statdisk or by reverting to the original Excel workbook, copying in Excel, exporting as a .csv file, and then importing into Statdisk. (Don’t say you weren’t warned!)
• Explain if you would characterize any or all of the TAA levels as approximately normally distributed for the controls and for the cases.
  • Provide plots and statistics in support of your conclusions.
• Explain if any of the TAAs are useful for discriminating between the cases and controls.
  • Provide plots and statistics in support of your conclusions.
• All writing assignments should be at least 250-500 words in APA format supported by scholarly sources.

BONUS. In the above, we pooled all cases together.  Summarize whether you think this is legitimate or whether the levels of any of the TAAs appear to differ significantly between the cases from China and the cases from Korea. Provide evidence in support of your conclusion.

Assignment 1

Assignment 1: Rationale and Analysis for Agency Selected, Part 1  

Refer to the Scenario for Assignments 1, 2, 3, 4, and 5

Write a 4 page paper, titled Rationale and Analysis for Agency Selected, Part 1

1.Provide background information about the agency’s key historical events, mission, and goals / objectives. (Title this section Introduction)

2.Describe at least three (3) functions of this agency, highlighting the public it serves. (Title this section Agency Functions)

3.Analyze at least two (2) current events involving the agency that might have implications to personnel management. (Use the e-Activities from Week 1 and Week 2.) (Title this section Agency News)

4.Explain the rationale for selecting this agency with at least two (2) justifiable reasons. (Title this section Rationale for Selecting Agency)

5.List at least four (4) academic sources and government Websites you expect to access in your research. (Include no more than one (1) non-government Website) 

Some websites you may want to access are:

•   U.S. Government Website 

•   Office of Personnel Management Website 

•   FedWorld Website 

Your assignment must follow these formatting requirements:

•   Be typed, double spaced, using Times New Roman font (size 12), with one-inch margins on all sides; citations and references must follow APA or school-specific format. Check with your professor for any additional instructions. When referencing Websites, make sure you follow APA formatting within the text and on the Reference Page.

•   Include a cover page containing the title of the assignment, the student’s name, the professor’s name, the course title, and the date. The cover page and the reference page are not included in the required assignment page length.

The specific course learning outcomes associated with this assignment are:

•   Analyze key historical and legislative events in the development of personnel management in the public sector. 

•   Analyze pertinent issues, such as motivation and productivity, collective bargaining, labor relations, equal employment opportunity (EEO), affirmative action (AA), intergovernmental relations, and / or professionalism, facing public personnel managers. 

•   Assess external organizational and employee conditions as well as their implications to and impact on personnel management. 

•   Develop a proposal for strategic public personnel management for a specific setting.

•   Use technology and information resources to research issues in public personnel management.

•   Write clearly and concisely about public personnel management using proper writing mechanics. 

Grading for this assignment will be based on answer quality, logic / organization of the paper, and language and writing skills. Click here to access the rubric for this assignment.

1. Compare and contrast each of the five organizational structures from your reading (functional, divisional, matrix, team-based, and virtual network).
2. If you were to choose one structure in which to work which would you choose and why?
3. Compare the organizational structures of Google and Walmart. 
4. Explain what types of control processes might be found in each of the organizational structures.
5. Describe what types of quality management processes might be found in each of the organizational structures.
6. Minimum of 500–600 words